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Abbreviations AD: Alzheimers disease CCK: Cholecystokinin CNS: Central nervous system CRF: Corticotropin-releasing factor DPP4i: Dipeptidyl peptidase-4 inhibitor FDA: Food and Drug Administration FOS: Fructooligosaccharides GERD: Gastroesophageal reflux disease GI: Gastrointestinal GIP: Glucose-dependent insulinotropic polypeptide GLP-1: Glucagon-like peptide-1 GLP-1 RA: Glucagon-like peptide-1 receptor agonist IPPW: Isolated pyloric pressure wave MMC: Migrating motor complex PYY: Peptide YY RCT: Randomized controlled trial SCFA: Short chain fatty acid T2DM: Type two diabetes mellitus References Yao H, et al

VGSCs have three functional states, as shown in Figure 5 (Mantegazza et al., 2010)

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