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Plasma levels of OXA are increased during fasting in humans (32) and are lower in obese subjects than normal-weight people (33), suggesting that peripheral OXA modulates food intake as an orexigenic peptide (34)

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The rationale for using subcutaneous semaglutide 1 mg specifically is: greater certainty of clinically important reductions to the persons risk of major adverse cardiovascular events and HbA 1c and weight , although it should be pointed out that evidence on the benefits of oral semaglutide and tirzepatide was not available at the time of guideline review

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