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FIGURE 1 Next, to determine the neurotoxic effect of peroxynitrite on cultured SGNs, the cultured SGNs were treated with different concentrations (100 or 200 M) of peroxynitrite for 24 or 48 h, respectively (Figure 2A)

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However, when the intensity of heat stress exceeds the cellular tolerance threshold, the cytoprotective effects of HSPs may be overwhelmed, permitting secondary inflammatory cascades (e.g., HMGB1/TLR4-mediated NF-B activation) to dominate, thereby exacerbating hepatocyte damage [16]

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