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Restrictive eating patterns inherently low in a variety of fiber, resistant starches, and polyphenol-rich foods diminish substrates required for diverse gut bacterial populations and adequate microbiome diversity
Since 2005, multiple GLP-1R agonists resembling exendin-4 have been developed ( Figure 2 ), with fatty-acid modifications to increase half-life and facilitate less frequent dosing regimes
Weighing the potential savings from reducing comorbidity against the competitive landscape of GLP1 drugs, the combination of lower upfront costs and improved wellness could contribute to broader acceptance of GLP1 use by health plans and policymakers
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