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Sweating accompanied by unexplained weight loss, fever, or persistent fatigue warrants prompt evaluation

DOX was acquired as an injection-grade vial (50 mg/50 mL, Mylan, Italy), SP as tablets (the active ingredient is included in 500 mg each pill, Puritans Pride Company, Inc., USA), and L-car as injection-grade ampoules (1 mg/5 mL/5 ampoules, Mepaco, Cairo)

The translational value of targeting cuproptosis and copper metabolism lies in the identification of key regulatory molecules (e.g., FDX1, DLAT, ATP7A/B) and potential biomarkers (e.g., serum CP and NCC) that could guide clinical decision-making

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