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Eur J Biochem 246:259273 Helmer DA, van Doren WW, Litke DR et al (2020) Safety, tolerability and efficacy of dietary supplementation with concord grape juice in Gulf war veterans with Gulf war illness: a phase I/IIA, randomized, double-blind, placebo-controlled trial

( Clarke, et al 2014 ) The term endocrine is defined as "Pertaining to hormones and the glands that make and secrete them into the bloodstream through which they travel to affect distant organs" ( medicinenet.com ) Clarke and his team argue that the gut microbiome acts as an endocrine organ because of it's ability to secrete compounds that act on distal organs such as the brain

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Amino acids like L-arginine may cause additive blood pressure-lowering effects when combined with antihypertensive medications or nitrates