Liver Fibrosis and Hepatic Stellate Cell Biology Hepatic fibrosis results from sustained HSC activation a transdifferentiation from quiescent lipid-storing pericytes to contractile, ECM-secreting myofibroblasts driven by TGF-1, PDGF-BB, and oxidative stress
One clinical trial showed that ipamorelin administered to healthy volunteers produced dose-dependent, pulsatile increases in growth hormone concentrations with predictable pharmacokinetics and without serious adverse effects, establishing its ability to stimulate GH release
The blend seems to offer a potential means to optimize growth hormone levels and may elicit effects on sleep, metabolic function, cognition, muscle tissue, lean mass, and lipid profiles
The mechanisms are paired, with follistatin allowing greater muscle growth possible while IGF1 LR3 provides the anabolic stimulus to realize that possible