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Type 2 diabetes mellitus (DM2) affects a 13.8% of the Spanish population1 and its prevalence is expected to increase in the future.2 The presence of DM2 increases significantly the risk of cardiovascular events, chronic kidney disease (CKD), and premature death3,4 and as its prevalence increases it is expected to rise the incidence of microvascular and macrovascular complications.5 Until the last decade, the control of blood glucose, blood pressure, dyslipidemia, and the use of inhibitors of the renin-angiotensin system (iSRA) have been the only strategies available to reduce cardiovascular and renal risk in this population

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Slowing gastric emptying: GLP-1 also slows down the rate at which the stomach empties its contents into the small intestine

Figure 2: Gross expenditures on GLP-1 AOMs in states that recently terminated coverage, in $ millions Gross expenditures for Wegovy, Zepbound, and Saxenda for all approved indications, including reducing the risk of MACE, MASH, and OSA