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Gastrointestinal symptoms - Diarrhea, constipation, abdominal discomfort, vomiting Reduced appetite - While this contributes to weight loss, some people find it makes eating adequate nutrition challenging Fatigue - Some individuals report feeling more tired, particularly in the first few weeks Injection site reactions - Redness, itching, or mild discomfort at injection sites (for injectable formulations) Most side effects are dose-dependent and tend to improve as the body adjusts

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In addition, caffeine can interfere with the kidneys ability to reabsorb sodium, which further reduces the bodys capacity to retain water