In this stimulated state, the brain signals that the body is satiated, effectively turning off the intense hunger cues that often lead to overeating
Before prescribing, clinicians should confirm appropriate indicationseither inadequately controlled type 2 diabetes or obesity with BMI 30 kg/m (or 27 kg/m with weight-related comorbidities such as hypertension or dyslipidemia)
Abbreviations AEs: adverse events BC: body composition BHB: -hydroxybutyrate BIA: bioelectrical impedance analysis BIVA: bioelectrical impedance vector analysis BMI: body mass index BW: body weight CT: computed tomography CVD: cardiovascular disease FM: fat mass FFM: free fat mass GI: gastrointestinal GLP-1: glucagon-like peptide-1 GLP-1RA: glucagon-like peptide-1 receptor agonist HFpEF: heart failure with preserved ejection fraction KD: ketogenic diet LBM: lean body mass MASH: metabolic dysfunction-associated steatohepatitis MD: Mediterranean diet MEAL: Muscle maintenance, Energy balance, Avoid side effects, Liquid intake MM: muscle mass MNT: medical nutrition therapy MRI: magnetic resonance imaging PUFA: polyunsaturated fatty acids RCTs: randomised controlled trials SCFAs: short-chain fatty acids STEP: Semaglutide Treatment Effect in People with obesity T2D: type 2 diabetes TNF: tumor necrosis factor VLCKDs: very-low-calorie ketogenic diets VLEKT: very low energy ketogenic therapy WC: waist circumference WHO: World Health Organization References Finucane MM, Stevens GA, Cowan MJ, Danaei G, Lin JK, Paciorek CJ, et al
To be safe and make this treatment work well, you should talk to your healthcare provider if you notice anything not right
