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They found that when people stop these medications after an average of 39 weeks of treatment, they generally regain weight rapidly, and their cardiometabolic markers return to pre-GLP-1 levels by 1.4 years after treatment has been discontinued

PD onset is marked by progressive degeneration of dopaminergic neurons within the substantia nigra, leading to diminished levels of striatal dopamine and its metabolites in the adult brain (75)

Apoptosis 20:14331443

Therefore, indirect regulation, via - or -cell products has been thought to be the primary mechanism by which GLP-1 inhibits glucagon secretion (Gromada et al., 2007