glp 1 blind Blindness and GLP-1 Drugs: An Ophthalmologist Explains A Big Week for GLP-1

The two drugs have generated billions of dollars in profits for the company, but that cash stream will start to dry up next year when semaglutide patents expire in some of the worlds biggest markets, including India, China, and Brazil

On histologic evaluation (table 1), 59% of explants had macrosteatosis, 91% had Mallory bodies, 84% had cytologic ballooning, 95% had lobular inflammation, 98% had portal inflammation, 70% had neutrophilic infiltration, 97% had bilirubinostasis, and 25% had megamitochondria

By engaging GLP-1 Rs across the gut-brain axis, these agents potentiate physiological satiety signals, slowing gastric emptying, suppressing hunger cues, and diminishing the hedonic appeal of calorie-dense foods

The 503A pharmacies preparing these formulations are regulated by state boards of pharmacy and subject to FDA oversight of the facility but the compounded products themselves do not go through the FDA's drug approval process