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By activating this pathway, ARA-290 is investigated for its potential to reduce inflammation and promote nerve repair without the cardiovascular side effects associated with systemic EPO administration

The formal scientific terminology "single agonist," "dual agonist," "triple agonist" is more accurate and is preferred in published research literature

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Common challenges target: composition claim scope (sequence variants, analogs, and pegylated or acylated differences), method-of-treatment claims (carve-outs around dosing regimens, endpoints, or indication), formulation and device (stability systems, delivery mechanics, and concentration/vehicle definitions), manufacturing process (where competitors alter cell lines or purification steps to avoid manufacturing claim coverage)