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Semaglutide Tirzepatide Mechanism GLP-1 only (single hormone) GLP-1 + GIP (dual hormone) Trial-average weight loss 13.7% of body weight (about 33.1 lbs) in SURMOUNT-5 20.2% of body weight (about 50.3 lbs) in SURMOUNT-5 Common side effects Nausea, constipation, reflux, usually early and fading Similar profile, sometimes stronger appetite suppression Optima pricing $249 for 10 weeks, all-inclusive $499 for 10 weeks, all-inclusive Best for Steady, proven weight loss at a lower price point The largest average reduction, if the cost fits your goals Both use the same active ingredients as the FDA-approved brand-name drugs, but Optima's compounded versions are prepared by licensed pharmacies and are not themselves FDA-approved

Ingredients: deionized water, BioGlute Complex (proprietary blend of glutathione and essential phospholipids), sodium hydroxide, potassium sorbate, grapefruit seed extract, lauric arginate (as preservatives)

Inverse relation between levels of p27Kip1 and of its ubiquitin ligase subunit Skp2 in colorectal carcinomas