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In SH3 and multiple ankyrin repeat domains 3 (Shank3) KO mice, a widely used mouse model with autistic-like social deficit and repetitive behavior, reduced cortical actin filaments and Rac1/PAK activity were observed, which were rescued by reactivating Rac1 or inhibiting cofilin activity ( Fragile X Syndrome Many Rho signaling proteins were reported to be linked to intellectual disability (Newey et al., 2005
Sarnelli G, Pesce M, Barbara G, de Bortoli N, Sario AD, Esposito G, Frazzoni M, Galloro G, Gatta L, Ghisa M, Londoni C, Marabotto E, Meggio A, Pisani A, Ribolsi M, Usai Satta P, Savarino V, Scarpignato C, Stanghellini V, Tosetti C, Visaggi P, Zingone F, Barberio B, Savarino EV (2025) Italian guidelines for the diagnosis and treatment of functional dyspepsiajoint consensus from the Italian societies of gastroenterology and endoscopy (SIGE), neurogastroenterology and motility (SINGEM), hospital gastroenterologists and endoscopists (AIGO), digestive endoscopy (SIED) and general medicine (SIMG)
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Regulation of brain tumor dispersal by NKCC1 through a novel role in focal adhesion regulation
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