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Changes at the neuronal level increases sensitivity for future stimulation

During treatment of the PDX model of osteosarcoma, since the individuality of the mice, the tumor volume of one mouse reached 1500 mm 3 by the end of the treatment, and this mouse was not euthanized in time to obtain reliable and intuitive experimental results

doi: 10.1089/AID.2014.0062 30 PlonkaPMPicardoMSlominskiAT

for instance, drugs designed to modulate brain mitochondria must penetrate the BBB, which can be achieved through nanoparticle conjugation or chemical modification to enhance lipophilicity [19]