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When you consume caffeine, it quickly enters your bloodstream and travels to the brain, where it blocks adenosine, a neurotransmitter that promotes relaxation and sleepiness

Dasu MR, Martin SJ

The postprandial rise in cortisol has been shown to be mediated via increased pituitary ACTH secretion, which is in turn is modulated by central stimulant alpha-1 adrenoreceptors (221)