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Of course, the combination of both functional impairments brings methodological difficulties, since motor disabilities can influence performance in cognitive and behavioral tests, and vice versa, behavioral changes can modify the results of motor tests

Savvides A, Ali S, Tester M, Fotopoulos V

Higher-risk situations may include: Older age Existing sarcopenia or frailty Recent falls Difficulty rising from a chair Low baseline physical activity Very low protein or calorie intake Rapid or excessive appetite suppression Chronic kidney, liver, pulmonary, or cardiovascular disease Cancer or another catabolic illness Recent hospitalization Significant gastrointestinal adverse effects Very rapid weight loss Inability to participate in resistance exercise These factors do not automatically make GLP-1 therapy inappropriate