glp 1 horror stories reddit Doctors and patients across social media are reporting a kind of emotional flattening while on GLP-1 drugs. Anecdotally, physicians describe meaningful mental health gains — greater self-esteem, less shame over eating and Understanding Migraines and GLP-1 Medications

While some patients may have less preference for once monthly as they may be more susceptible to forgetfulness, generally most would prefer a less burdensome dosing regimen and help improve compliance

Adverse effects such as tachycardia, infections, headaches, dizziness, nausea, vomiting, diarrhea, and dyspepsia, as well as contraindications such as a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2, hypersensitivity, severe gastrointestinal diseases, renal impairment, and pregnancy have been noted

Conclusion The upper gastrointestinal tract plays a primary role in the regulation of glucose excursions in response to meal ingestion by determining the rate of gastric emptying and indirectly by regulating appetite and satiation, barrier integrity, and nutrient absorption

Similar results were obtained with cynomolgus monkey GLP-1R (Fig