glutathione metabolism kegg Genome-Scale Metabolic Modeling Reveals Sequential Dysregulation of in Livers from Patients with Alcoholic Hepatitis Evaluating the Impact of Two

Oxidation of GSH during sample preparation (Nuhu et al., 2020, Tomin et al., 2021) can also lead to an under-estimation of GSH and an over-estimation of GSSG concentrations (Nuhu et al., 2020)

We describe the use of glutathione (GSH) for this purpose, which is present at elevated levels (10 mM) in various cancer cells [7]

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Considering that the use of metformin and simvastatin led to increased apoptosis and decreased mitochondrial membrane potential in glioma cell lines, we speculate whether these two drugs cause DNA damage in glioma cells