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The landmark SURMOUNT5 trial (NCT05822830) randomised 751 adults with obesity (without diabetes) to either the maximum tolerated dose of tirzepatide (10 mg or 15 mg) or semaglutide (1.7 mg or 2.4 mg)

Jul 2020;38(3):308-322

It's essential for converting food into energy and maintaining healthy cellular functions

"I would drink something and within minutes, like five, 10 minutes later, I would be throwing up." In a statement to CBS News, Novo Nordisk said gastrointestinal, or GI, events are "well-known side effects of the GLP-1 class." "For semaglutide, the majority of GI side effects are mild to moderate in severity and of short duration