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Although no differences in safety or efficacy were observed between older and younger subjects, the number of subjects aged 65 and over is not sufficient to determine whether they respond differently from younger subjects [see Clinical Pharmacology (12.3 )]

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Furthermore, the number of T cells (CD3), B cells (CD19) and macrophages (CD68) was increased in the lamina propria of new-onset treatment-nave RA patients (Fig