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This research is largely driven by early biomarker discoveries showing that many ME/CFS patients suffer from a deficiency in serum acylcarnitine, which directly impairs mitochondrial oxidative phosphorylation

After treatment, cells were immediately analyzed for apoptosis and the cell cycle using a BD FACSCelesta Cell Analyzer with an Annexin V-FITC/PI Apoptosis Detection Kit and PI/RNase Staining Buffer (BD Biosciences, Franklin Lakes, NJ, USA), respectively, according to the manufacturers instructions

Some first-generation agents, like haloperidol, are also less likely to cause metabolic syndrome (Editors note: See Metabolic Side Effects of Antipsychotics table, below)