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doi:10.1111/j.1365-2672.2008.03892.x Liang G, Liao X, Du G, Chen J (2009) A new strategy to enhance glutathione production by multiple H2O2 induced oxidative stresses in Candida utilis

1 Introduction Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) characterized by immune-mediated demyelination accompanied by axonal and neuronal damage ( Clinically, MS affects both the brain and spinal cord and is categorized into distinct phenotypic subtypes: relapsing-remitting MS (RRMS), primary progressive MS (PPMS), and secondary progressive MS (SPMS) ( Since interferon- (IFN-) was approved for the treatment of RRMS in 1993, substantial progress has been made in targeting peripheral immune-driven inflammatory processes through a range of anti-inflammatory and immunomodulatory therapies ( 2 OS in MS 2.1 OS Mitochondria are the principal intracellular source of reactive oxygen species (ROS)