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For obesity management, NICE technology appraisal TA875 recommends semaglutide (Wegovy) only within specialist weight management services, for people with a BMI of at least 35 kg/m (or 30 kg/m with weight-related comorbidities) and as part of a programme including diet and physical activity for a maximum of 2 years

The Gila monster discovery demonstrated that long-acting GLP-1 receptor activation was possible and beneficial, guiding scientists to develop human-based analogues with similar properties

Stopping and restarting certain GLP-1s to lose weight may make the drug less effective A preclinical study reveals that people seeking weight loss from GLP-1s may need to consistently take the medication long term

Methods A multinational cross-sectional study was conducted across all six World Health Organization regions, involving community-dwelling adults