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What are the signs of B12 deficiency

Enemas have been used therapeutically since 1500 BC

1-(3-(4-amino-3-(4-(3-ethynylphenoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-2-chloroethanone ( 17 ) Yield: 66% yellow solid, 1 H NMR (500 MHz, CDCl 3 ) 8.36 (d, J = 11.5 Hz, 1H), 7.68 (d, J = 8.3 Hz, 2H), 7.397.30 (m, 2H), 7.227.16 (m, 3H), 7.11 (d, J = 8.0 Hz, 1H), 5.91 (bs, 2H), 5.034.86 (m, 1H), 4.834.42 (m, 1H), 4.254.15 (m, 1H), 4.12 4.04 (m, 1H), 4.003.81 (m, 1H), 3.523.22 (m, 1H), 3.12 (s, 1H), 2.95 (t, J = 11.4 Hz, 1H), 2.552.20 (m, 2H), 2.091.62 (m, 3H) ppm

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