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Overall, our data indicate that moderate doses of ibuprofen can affect liver more significantly than previously reported and include proteasome dysfunction, increased levels of H 2 O 2 , impaired glycolytic pathways and altered fatty acid synthesis and oxidation

The autophagy adaptor p62/SQSTM1, essential for targeting ubiquitinated substrates to autophagosomes, is mutated in ALS and FTD, where impaired p62 function results in aggregation-prone protein accumulation and neuronal toxicity

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