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This study aimed to determine the impact of sleeping habits on the weight loss effect of semaglutide, an oral GLP-1 RA, among Japanese individuals with obesity

Given these findings, semaglutide may have anti-inflammatory properties, helping reduce inflammation in the knee joint, a key contributor to pain

Early clinical studies and translational research have explored their impact on depressive symptoms, anxiety, and neuroinflammation, particularly in patients with comorbid metabolic dysfunction

Both aerobic exercise and resistance training have been shown to improve insulin sensitivity and may influence incretin hormone responses, though effects on GLP-1 levels specifically are variable across studies