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In a major clinical trial published in The New England Journal of Medicine , patients taking retatrutide lost an average of about 24% of their body weight after 48 weeks

ZEPBOUND **General Notes:**- All listed drugs are administered as once-weekly subcutaneous injections.- Off-label use for weight loss has been common for Ozempic and Mounjaro prior to the approval of Wegovy and Zepbound for obesity.- Dosages vary by patient needs and indication but typically start at lower doses and are titrated up.- Main risks under emerging research include potential severe vision complications (e.g., NAION) in addition to commonly known side effects

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Although preliminary data are encouraging, especially regarding the reduction of inflammation and body weight, open questions remain regarding the effects of these drugs on a longer time scale and on different patient subgroups