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Clinically meaningful responses in insulin-resistant patients typically include a reduction in fasting insulin of 20-40% and an improvement in HOMA-IR within 8-12 weeks at therapeutic doses, though individual variability is wide [1]

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For example, with reference to the clinical ocular trials mentioned in Sosne and Kleinman, the researchers noted that no long-term safety studies have been done with TI34 treatment in the eye for more than a month

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