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Large-scale purification was performed and the complexes were collected by SEC for cryo-EM studies, with all components of the complex identified in SDS-PAGE of the SEC peak (Supplementary Fig

modification Obesity and IBD by @EdwardLoftus2 Obesity is a chronic inflammatory state Adipose tissue is not biologically inert (TNFa, IL-6, IL-8, leptin, adiponectin) Postulated role in the pathogenesis of IBD Potential risk factor for adverse outcomes Trends in BMI among IBD patients at diagnosis in Olmsted County Doubling of obesity rates in 20 years in CD and UC (Johnson AM JCC 2021 and J Clin Gastro 2024) Obese patients more likely to have a colonic phenotype

Supported by: Australian NHMRC Project Grants Disclosure: M.L.H