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( g-i ) Characterization of LiKO mice, including body weight ( g ), circulating glucose ( h ), and insulin ( i )

however, it has been hypothesized that the presence of extracellular HMGB1 contributes to selective vulnerability of neuronal subpopulations (e.g., pyramidal and granule cell neurons) to hyperexcitability and synaptic dysfunction within the inflammatory environment, further augmenting seizure activity [48,51]