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In murine bleomycin models, 20 additional ferroptosislinked genes (e.g., ALOX15, CDO1, JUN, SLC2A1, GPX2) were differentially expressed in fibrotic versus normal lung ( Taken together, these biomarkers capture complementary facets of ferroptosisupstream iron dysregulation, core lipid peroxidation events, failed antioxidant defenses, and downstream gene expression changes

Notably, SREBP1 is overexpressed in some digestive system cancers, including pancreatic and colon cancers, where it has been shown to promote tumor proliferation and invasion [67, 68] (Fig

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Vitamin E is a family of eight fat-soluble compounds: four tocopherols and four tocotrienols