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These might act peripherally (i.e., bile duct ligation), centrally (i.e., huge intraventricular hemorrhage), and then peripherally and centrally, and centrally and peripherally, along with the three interconnected body cavities, as specifically shown in the maintained intra-abdominal hypertension studies [22], as the disturbances may be rapidly transmitted from the periphery to centrally, and from centrally to the periphery, through the venous system

Unlike Arginine, L-Citrulline does not cause diarrhoea and produces a long-lasting effect rather than the spike produced by Arginine