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Each node represents a different drug intervention, in which the oral route was the well-connected route of administration with all other routes directly linked to it

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The APLN/APLNR pathway is upregulated in malignant cells in many tumor types [174, 176, 177], as well as in tumor endothelial cells [178], and elevated Apelin levels are associated with disease progression and poor clinical outcome [176, 179,180,181]

[15] [16] This adaptive thermogenesis means that maintaining weight loss requires fewer calories than would be expected for someone of the same weight who was never overweight