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In rodents, SPNs in the C8-T2 segments innervate primarily the superior cervical and middle cervical-stellate ganglion complex 43,44,45,46,47,48,49 , from which postganglionic neurons innervate the heart, salivary glands and the eyes, among other targets 47,50,51,52

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Psoriasis has also been associated with defensin, the Th2 pathway involving IL-4 and IL-13, and adaptive immunity involving CD8 T cells