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A metabolite of acetaminophen also acts on the TRPV1 and TRPA1 receptors to decrease pain.[ref] While generally safe when taken as directed, higher doses of acetaminophen can lead to severe liver damage and potentially fatal liver failure

Glutathione-Protected Gold Clusters Revisited: Bridging the Gap between Gold(I)Thiolate Complexes and Thiolate-Protected Gold Nanocrystals

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Open uncontrolled studies reported selected observations, but FDA found insufficient evidence of effectiveness