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mTORC1 activates mitochondrial transcripts through 4E-BP1 and stimulates mitochondrial biogenesis by driving PGC1 (Summer et al., 2019)

Consistently, in an in vivo/in vitro study using a focal cerebral cortical ischemic mouse model and cultures of cortical neurons under oxidative stress, liraglutide promoted brain repair after cerebral ischemic injury and reduced oxidative stress, through SIRT1mediated mitochondrial improvement [91]

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