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[7] who conducted a study to detect the risk of biliary-related diseases in patients with T2D using GLP-1RAs versus sodium glucose co-transporters 2 inhibitors (SGLT2I)

J Clin Endocrinol Metab 97 , 37993806, (2012)

Administration of semaglutide at the dose regimen of ~ 90 g/kg/day failed to evidence significant weight loss but more importantly, led to alteration of cortical bone microarchitecture, represented by lower cortical thickness, and ultimately to a significant decrease in bone strength [69]

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