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OMIM 176270) is a relatively common (prevalence 1/15 0001/30 000) generally sporadic disorder with a recognizable pattern of dysmorphic features and major neurologic, cognitive, endocrine and behavioral/psychiatric disturbances

Greater weight loss during treatment was associated with greater rebound, suggesting biological adaptations, potentially involving changes in appetite hormones, metabolism, or reward sensitivitythat increase susceptibility to weight regain [141]

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N., Magliano, D