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A meta-analysis of five trials in participants with either impaired fasting glucose, type 2 diabetes mellitus, or nonalcoholic steatohepatitis found evidence of an improvement in insulin resistance with supplemental L-carnitine compared to placebo (43)

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c , Time course of plasma insulin concentrations in fasted, anesthetized Wistar rats treated with either vehicle, GLP-1(7-36) (3 nmol/kg), LSN3160440 (5 mg/kg), GLP-1(9-36) (50 nmol/kg), or LSN3160440 (5 mg/kg) plus 5, 20, or 50 nmol/kg of GLP-1(9-36), dosed immediately before intravenous administration of a glucose bolus (0.5 g/kg)