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Empagliflozin is not recommended for glycemic control in patients with an eGFR 10-fold more potent in inhibiting SGLT-1 (238)

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The SUPRPASS-4 trial (262), involving 2002 participants with high-risk cardiovascular profiles followed for up to 104 weeks, showed no difference in 4-MACE events (cardiovascular death, myocardial infarction, stroke, and hospitalization for unstable angina) with tirzepatide compared to insulin glargine (HR 0.74

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