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In the long-term studies conducted by Khavinson and his team, subjects followed for up to 15 years showed no significant toxicity or negative outcomes attributable to epithalon use

While knee injections are typically safe and risk of complication is quite low, there are some potential adverse effects

The takeaway is that the sublingual route consistently outperforms oral swallowing, and the margin is clinically meaningful

Among the most frequently reported adverse effects are minor and self-limiting such as local injection site erythema, transient hormonal shifts, and receptor desensitization with prolonged or high-frequency use