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While waist circumference reduction showed a modest association with cardiovascular benefit, it accounted for only 33% of semaglutide's treatment effect on major adverse cardiovascular events.[1] This suggests that the majority of cardiovascular benefit occurs through mechanisms beyond adiposity reductionincluding direct effects on inflammation, endothelial function, blood pressure, and lipid metabolism

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It can help protect against various diseases like neurological disorders, liver disease, heart conditions, autoimmune disorders, respiratory diseases, and more