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3 Possible mechanisms of lycopene in managing premalignant lesions of digestive tract 3.1 Antioxidative mechanisms Lycopene is a potent antioxidant and has strong capacity to protect against oxidative damage, therefore playing a crucial role in treating selected disorders associated with oxidative stress, including some of the precancerous lesions (Figure 1)

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Poly(ADP-ribose) polymerase is a catalytic dimer and the automodification reaction is intermolecular