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Comparacin con Factores de Crecimiento Relacionados MGF (Mechano Growth Factor) MGF es una variante de splicing de IGF-1 (IGF-1Ec en humanos): Origen : Expresado localmente en msculo en respuesta a estrs mecnico Funcin : Activacin de clulas satlite musculares Mecanismo : Sealizacin diferente a IGF-1 cannico Vida media : Muy corta (~minutos) debido a degradacin rpida Accin : Predominantemente autocrina/paracrina PEG MGF (PEGylated MGF) Versin pegilada de MGF para mayor estabilidad: Modificacin : Polietilenglicol conjugado Vida media : Significativamente mayor que MGF nativo Distribucin : Sistmica vs