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With access to a massive database of electronic health record data at our disposal, we looked for noticeable associations in these data between semaglutide use and incidence of cannabis use disorder

Insulin Secretion: In response to high blood sugar, they help increase the bodys insulin production, which lowers blood glucose levels

In a randomized, double-blind, placebo-controlled crossover trial of 30 adults with obesity (Effects of once-weekly semaglutide on appetite, energy intake, control of eating, food preference and body weight in subjects with obesity, Blundell and colleagues, Diabetes, Obesity and Metabolism , 2017), 12 weeks of once-weekly semaglutide titrated to 1.0 mg was associated with less hunger, fewer food cravings, better control of eating, and a lower preference for high-fat foods

This pattern reflects the medication's role in appetite control rather than a permanent metabolic reset