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Both initial and maintenance probings are intended to mechanically open Meibomian gland orifices and ducts, remove obstructions, maintain patency of orifices and ducts, restore gland function, increase oil production (qualitatively and quantitatively), and stabilize the tear film, thus relieving symptoms of Meibomian gland dysfunction, blepharitis, ocular rosacea, and dry eye

During bacterial infections, CD8 + T cells increase the expression levels of genes related to serine and glycine synthesis, one-carbon metabolism, the folate cycle, and nucleotide synthesis [263]

Persistent dyspepsia is one of the most frequent side effects of NSAIDs and with few exceptions it can be an indicator of onset of future gastrointestinal (GI) toxicity

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