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Patients were excluded if they had GLP-1 exposure of less than six months

Considering that the protein synthesis process demands a considerable amount of ATP, in the future, the focus should be on exploring the regulation of L-citrulline on mitochondrial function and the connection between this regulation and protein synthesis, as this is intimately related to the combined efficacy of L-citrulline and energy supplements

2.1 Given these gaps, we propose the following recommendations based on current evidence 2.1.1 For clinicians We propose a clinical medication use management process that encompasses review, screening, combination therapy, education, monitoring, and follow-up (Table 3)