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Simultaneous determination of loganin, morroniside, catalpol and acteoside in normal and chronic kidney disease rat plasma by UPLC-MS for investigating the pharmacokinetics of Rehmannia glutinosa and Cornus officinalis Sieb drug pair extract

Molecular Structure Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Q-Glu-Gln-Gly-Ala-Ser-Ala-Arg-Leu-Gly-Glu-Gly-Gln-Ala Molecular Formula: CHNO Molecular Weight: 3367.9 g/mol PubChem CID: 91976842 CAS #: 863288-34-0 Other Known Titles: CJC-1295 Without DAC Source: PubChem Key Actions Research on CJC-1295 (without DAC) shows a range of physiological and cellular effects related to its ability to stimulate natural GH release

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These mutations result in decreased lysosomal function, impairing the processing of -Syn and leading to lipid accumulation and subsequent neurodegeneration